Chemistry: A European Journal 2013-03-18

β-Siloxy-α-haloketones through highly diastereoselective single and double mukaiyama aldol reactions.

Jakub Saadi, Hisashi Yamamoto

文献索引：Chemistry 19(12) , 3842-5, (2013)

摘要

Double-action haloketones: A super silyl group enabled the first highly diastereoselective Mukaiyama aldol reactions of α-chloro- and α-fluoroketones with a wide range of aldehydes, providing anti-β-siloxy-α-haloketones. This process is compatible with one-pot double-aldol methodology and allows for rapid access to new halogen-modified polyketide fragments bearing up to four contiguous stereocenters.Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

结构式	名称/CAS号	分子式	全部文献
	3,5-二溴苯甲醛 CAS:56990-02-4	C₇H₄Br₂O

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β-Siloxy-α-haloketones through highly diastereoselective single and double mukaiyama aldol reactions.

摘要

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