Structure–activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH

S Kirubakaran, SK Gorla, L Sharling, M Zhang…

文献索引：Kirubakaran, Sivapriya; Gorla, Suresh Kumar; Sharling, Lisa; Zhang, Minjia; Liu, Xiaoping; Ray, Soumya S.; MacPherson, Iain S.; Striepen, Boris; Hedstrom, Lizbeth; Cuny, Gregory D. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1985 - 1988

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被引用次数: 26

摘要

Cryptosporidium parasites are important waterborne pathogens of both humans and animals. The Cryptosporidium parvum and Cryptosporidium hominis genomes indicate that the only route to guanine nucleotides is via inosine 5′-monophosphate dehydrogenase (IMPDH). Thus the inhibition of the parasite IMPDH presents a potential strategy for treating Cryptosporidium infections. A selective benzimidazole-based inhibitor of C. parvum ...