Journal of the American Chemical Society

Inactivation of. alpha.-chymotrypsin with methyl-, trideuteriomethyl-, and trifluoromethyl-substituted N-phenyl-. alpha.-bromoacetamides

EW Bittner, JTC Gerig

文献索引：Bittner,E.W.; Gerig,J.T. Journal of the American Chemical Society, 1970 , vol. 92, p. 2114 - 2118

全文：HTML全文

被引用次数: 9

摘要

Abstract: The kinetics of the irreversible reaction of 0-, rn-, and p-methyl-and-trifluoromethyl- substituted N-phenyl-a-bromoacetamides with a-chymotrypsin have been studied at pH 6.0. Dissociation constants for the initially formed enzyme-inhibitor complexes have been determined or estimated and rate constants for reaction of these complexes to give inhibited proteins have been obtained. The para position seems to be most sensitive to substitution; ...