Models for nicotinamide coenzymes. Isotope effect discrepancies in the reaction of dihydronicotinamides with trifluoroacetophenone are due to adduct formation

…, R Yaniv, P Van Eikeren

文献索引：Chipman, David M.; Yaniv, Ruth; Eikeren, Paul van Journal of the American Chemical Society, 1980 , vol. 102, # 9 p. 3244 - 3246

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被引用次数: 64

摘要

Several years ago we suggested that the oxidation-reduction reaction of a 1, 4- dihydronicotinamide (1) with trifluoroacetophenone (2)(Scheme I) proceeds via an intermediate.'This was based on our observation that isotope effects determined by comparison of the rates of disappearance of protio-and 4-deuteriodihydronicotinamides (1 and 1-d I)* were small compared with those determined from the partitioning of hydrogen ...