Tetrahedron

Effective nucleophilic trifluoromethylation with fluoroform and common base

J Russell, N Roques

文献索引：Russell, Jamie; Roques, Nicolas Tetrahedron, 1998 , vol. 54, # 45 p. 13771 - 13782

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被引用次数: 76

摘要

Common bases (alcoholate, dimsyl anion or amide) are able to deprotonate trifluoromethane to form a trifluoromethyl anion equivalent. In this reaction DMF plays a crucial role of stabilisation. Trifluoromethyl aryl alcohols, ketones or sulfides can be obtained in good yields with the new reagent CF3H/Base/DMF.