The Journal of Organic Chemistry

Preparation of. beta.,. beta.-difluoro-. alpha.-(trifluoromethyl) styrenes by palladium-catalyzed coupling of aryl iodides with pentafluoropropen-2-ylzinc reagent

PA Morken, DJ Burton

文献索引：Morken, Peter A.; Burton, Donald J. Journal of Organic Chemistry, 1993 , vol. 58, # 5 p. 1167 - 1172

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被引用次数: 63

摘要

@,@-Difluoro-a-(trifluoromethy1) styrenes (DFT styrenes) are useful building blocks in organofluorine chemistry. The unique biological properties' that fluorine imparts to organic molecules are well-known, and the title compounds have been utilized as precursors for the preparation of antiinflammatory2 and antifertility3 compounds. DFT styrenes also find useful application as monomers: since fluorine enhances the thermal and chemical stability of ...