Helvetica chimica acta

Effective Methods for the Synthesis of N??Methyl β??Amino Acids from All Twenty Common α??Amino Acids Using 1, 3??Oxazolidin??5??ones and 1, 3??Oxazinan??6??ones

AB Hughes, BE Sleebs

文献索引：Hughes, Andrew B.; Sleebs, Brad E. Helvetica Chimica Acta, 2006 , vol. 89, # 11 p. 2611 - 2637

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被引用次数: 18

摘要

Abstract N-Methyl β-amino acids are generally required for application in the synthesis of potentially bioactive modified peptides and other oligomers. Previous work highlighted the reductive cleavage of 1, 3-oxazolidin-5-ones to synthesise N-methyl α-amino acids. Starting from α-amino acids, two approaches were used to prepare the corresponding N-methyl β- amino acids. First, α-amino acids were converted to N-methyl α-amino acids by the so- ...