Bioorganic & Medicinal Chemistry Letters 2012-12-15

Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate

Dhaneshwar Suneela, Patil Dipmala

文献索引：Bioorg. Med. Chem. Lett. 22(24) , 7582-7, (2012)

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摘要

A novel gastro-sparing prodrug of rhein and boswellic acid was designed for the management of osteoarthritis and its synthesis, characterization and pharmacokinetic profile is reported. The prodrug was activated by hydrolysis releasing rhein (91%) and boswellic acid (84.37%) in rat blood over a period of 7h upon its oral administration.