Synthesis of 2-imidazolidinylidene propanedinitrile derivatives as stimulators of gastrointestinal motility. 1

S Sasho, H Obase, S Ichikawa, T Kitazawa…

文献索引：Sasho; Obase; Ichikawa; Kitazawa; Nonaka; Yoshizaki; Ishii; Shuto Journal of Medicinal Chemistry, 1993 , vol. 36, # 5 p. 572 - 579

全文：HTML全文

被引用次数: 34

摘要

Alterations in the motility of the alimentary canal are associated with many symptoms of gastrointestinal disease. Examples of the digestive diseases that are manifested by a disturbance in motor activity are dysphagia, gastric stasis, vomiting, abdominal pain, paralytic ileus, and constipation. A number of gastrointestinalmotility enhancing agenta, such as metoclopramide (3), neostigmine (41, and bethanechol, have been developed to ...