Functional Group Tolerant Kumada− Corriu− Tamao Coupling of Nonactivated Alkyl Halides with Aryl and Heteroaryl Nucleophiles: Catalysis by a Nickel Pincer …

O Vechorkin, V Proust, X Hu

文献索引：Vechorkin, Oleg; Proust, Valerie; Hu, Xile Journal of the American Chemical Society, 2009 , vol. 131, # 28 p. 9756 - 9766

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被引用次数: 176

摘要

A nickel (II) pincer complex [(MeNN2) NiCl](1) catalyzes Kumada− Corriu− Tamao cross coupling of nonactivated alkyl halides with aryl and heteroaryl Grignard reagents. The coupling of octyl bromide with phenylmagnesium chloride was used as a test reaction. Using 3 mol% of 1 as the precatalyst and THF as the solvent, and in the presence of a catalytic amount of TMEDA, the coupling product was obtained in a high yield. The reaction ...

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1-(2-溴乙基)-4-氯苯

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