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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis of substituted 4 (Z)-(methoxyimino) pentyl-1-piperidines as dual NK 1/NK 2 inhibitors

…, JF Lee, JC Anthes, NY Shih, JJ Piwinski

文献索引：Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494

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被引用次数: 21

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The NK 1 and NK 2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl )-4(Z)-(methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors. ... A series of 4(Z)-(methoxyimino)pentyl- ...

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4-(哌啶-4-基甲基)吗啉结构式

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3-(1-boc-哌啶-4-甲基)哌啶-1-羧酸乙酯结构式

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N-Boc-4-哌啶甲醇结构式

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3-(1-boc-哌啶-4-甲基)哌啶-1-羧酸乙酯结构式

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1-Boc-哌啶-4-甲醛结构式

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3-(1-boc-哌啶-4-甲基)哌啶-1-羧酸乙酯结构式

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1-Boc-4-(3-carbamoylpiperidin-1-ylmethyl)piperidine结构式

1-Boc-4-(3-carb...

二碳酸二叔丁酯结构式

二碳酸二叔丁酯

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1-Boc-4-(3-carbamoylpiperidin-1-ylmethyl)piperidine结构式

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N-Boc-4-哌啶甲醇结构式

N-Boc-4-哌啶甲醇

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1-Boc-4-(3-carbamoylpiperidin-1-ylmethyl)piperidine结构式

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3-哌啶甲酰胺结构式

3-哌啶甲酰胺

1-Boc-哌啶-4-甲醛结构式

1-Boc-哌啶-4-甲醛

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1-Boc-4-(3-carbamoylpiperidin-1-ylmethyl)piperidine结构式

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4-哌啶甲醇结构式

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1-Boc-4-(3-hydroxyMethylpiperidin-1-ylmethyl)piperidine结构式

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二碳酸二叔丁酯结构式

二碳酸二叔丁酯

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1-Boc-4-(3-hydroxyMethylpiperidin-1-ylmethyl)piperidine结构式

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N-Boc-4-哌啶甲醇结构式

N-Boc-4-哌啶甲醇

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1-Boc-4-(3-hydroxyMethylpiperidin-1-ylmethyl)piperidine结构式

1-Boc-4-(3-hydr...

2-吡咯烷酮结构式

N-苄基-4-哌啶酮结构式

N-苄基-4-哌啶酮

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1-(1-苄基哌啶-4-基)吡咯烷-2-酮结构式

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4-哌啶甲醇结构式

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1-Boc-4-吗啉-4-基甲基-哌啶结构式

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二碳酸二叔丁酯

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1-Boc-4-吗啉-4-基甲基-哌啶结构式

1-Boc-4-吗啉-4-基甲基-哌啶

N-Boc-4-哌啶甲醇结构式

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1-Boc-4-吗啉-4-基甲基-哌啶结构式

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1-Boc-4-(2-thioxopiperidin-1-ylmethyl)piperidine结构式

1-Boc-4-(2-thio...

二碳酸二叔丁酯结构式

二碳酸二叔丁酯

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1-Boc-4-(2-thioxopiperidin-1-ylmethyl)piperidine结构式

1-Boc-4-(2-thio...

N-Boc-4-哌啶甲醇结构式

N-Boc-4-哌啶甲醇

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1-Boc-4-(2-thioxopiperidin-1-ylmethyl)piperidine结构式

1-Boc-4-(2-thio...

哌啶-2-硫酮结构式

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1-Boc-哌啶-4-甲醛结构式

1-Boc-哌啶-4-甲醛

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1-Boc-4-(2-thioxopiperidin-1-ylmethyl)piperidine结构式

1-Boc-4-(2-thio...

4-哌啶甲醇结构式

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1-(哌啶-4-甲基)哌啶结构式

1-(哌啶-4-甲基)哌啶

N-Boc-4-哌啶甲醇结构式

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1-(哌啶-4-甲基)哌啶结构式

1-(哌啶-4-甲基)哌啶

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1-Boc-哌啶-4-甲醛

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1-(哌啶-4-甲基)哌啶结构式

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1-(1-benzylpiperidin-4-yl)pyrrolidin-3-ol结构式

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1-(4-哌啶基)-3-吡咯烷醇结构式

1-(4-哌啶基)-3-吡咯烷醇

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1-(4-哌啶基)-3-吡咯烷醇结构式

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1-Boc-4-[2-(2-hydroxyethyl)piperidin-1-ylmethyl]piperidine结构式

1-Boc-4-[2-(2-h...

二碳酸二叔丁酯结构式

二碳酸二叔丁酯

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1-Boc-4-[2-(2-hydroxyethyl)piperidin-1-ylmethyl]piperidine结构式

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N-Boc-4-哌啶甲醇结构式

N-Boc-4-哌啶甲醇

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1-Boc-4-[2-(2-hydroxyethyl)piperidin-1-ylmethyl]piperidine结构式

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2-哌啶乙醇结构式

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1-Boc-4-[2-(2-hydroxyethyl)piperidin-1-ylmethyl]piperidine结构式

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1-Boc-4-(3-isopropylcarbamoyloxypiperidin-1-ylmethyl)piperidine结构式

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二碳酸二叔丁酯结构式

二碳酸二叔丁酯

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1-Boc-4-(3-isopropylcarbamoyloxypiperidin-1-ylmethyl)piperidine结构式

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N-Boc-4-哌啶甲醇结构式

N-Boc-4-哌啶甲醇

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1-Boc-4-(3-isopropylcarbamoyloxypiperidin-1-ylmethyl)piperidine结构式

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4-哌啶甲醇结构式

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1-Boc-4-(3-benzyl-2-oxopiperidin-1-ylmethyl)piperidine结构式

1-Boc-4-(3-benz...

二碳酸二叔丁酯结构式

二碳酸二叔丁酯

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1-Boc-4-(3-benzyl-2-oxopiperidin-1-ylmethyl)piperidine结构式

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1-Boc-4-(3-benzyl-2-oxopiperidin-1-ylmethyl)piperidine结构式

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3-phenylmethyl-2-piperidinone结构式

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1-Boc-哌啶-4-甲醛结构式

1-Boc-哌啶-4-甲醛

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1-Boc-4-(3-benzyl-2-oxopiperidin-1-ylmethyl)piperidine结构式

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4-[(3-羟基-1-哌啶基)甲基]-1-哌啶羧酸 1,1-二甲基乙酯结构式

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4-[(3-羟基-1-哌啶基)甲基]-1-哌啶羧酸 1,1-二甲基乙酯结构式

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4-[(3-羟基-1-哌啶基)甲基]-1-哌啶羧酸 1,1-二甲基乙酯结构式

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3-羟基哌啶结构式

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4-[(3-羟基-1-哌啶基)甲基]-1-哌啶羧酸 1,1-二甲基乙酯结构式

4-[(3-羟基-1-哌啶基)...

Synthesis of substituted 4 (Z)-(methoxyimino) pentyl-1-piper...

[Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 491 - 494]

Synthesis of substituted 4 (Z)-(methoxyimino) pentyl-1-piper...

[Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 491 - 494]

Synthesis of substituted 4 (Z)-(methoxyimino) pentyl-1-piper...

[Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 491 - 494]