e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis of substituted 4 (Z)-(methoxyimino) pentyl-1-piperidines as dual NK 1/NK 2 inhibitors

…, JF Lee, JC Anthes, NY Shih, JJ Piwinski

Index: Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494

Full Text: HTML

Citation Number: 21

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The NK 1 and NK 2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl )-4(Z)-(methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors. ... A series of 4(Z)-(methoxyimino)pentyl- ...

1-Boc-4-Morpholin-4-ylmethyl-piperidine Structure

1-Boc-4-Morphol...

~99%

4-(piperidin-4-ylmethyl)morpholine Structure

4-(piperidin-4-...

4-Piperidinemethanol Structure

4-Piperidinemethanol

~%

Ethyl 3-(1-Boc-piperidin-4-ylmethyl)piperidine-1-carboxylate Structure

Ethyl 3-(1-Boc-...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

Ethyl 3-(1-Boc-piperidin-4-ylmethyl)piperidine-1-carboxylate Structure

Ethyl 3-(1-Boc-...

1-Boc-4-piperidinemethanol Structure

1-Boc-4-piperid...

~%

Ethyl 3-(1-Boc-piperidin-4-ylmethyl)piperidine-1-carboxylate Structure

Ethyl 3-(1-Boc-...

1-Boc-piperidine-4-carboxaldehyde Structure

1-Boc-piperidin...

ethyl nipecotate Structure

ethyl nipecotate

~%

Ethyl 3-(1-Boc-piperidin-4-ylmethyl)piperidine-1-carboxylate Structure

Ethyl 3-(1-Boc-...

4-Piperidinemethanol Structure

4-Piperidinemethanol

~%

1-Boc-4-(3-carbamoylpiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-carb...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

1-Boc-4-(3-carbamoylpiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-carb...

1-Boc-4-piperidinemethanol Structure

1-Boc-4-piperid...

~%

1-Boc-4-(3-carbamoylpiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-carb...

Nipecotamide Structure

1-Boc-piperidine-4-carboxaldehyde Structure

1-Boc-piperidin...

~%

1-Boc-4-(3-carbamoylpiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-carb...

4-Piperidinemethanol Structure

4-Piperidinemethanol

~%

1-Boc-4-(3-hydroxyMethylpiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-hydr...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

1-Boc-4-(3-hydroxyMethylpiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-hydr...

1-Boc-4-piperidinemethanol Structure

1-Boc-4-piperid...

~%

1-Boc-4-(3-hydroxyMethylpiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-hydr...

2-Pyrrolidinone Structure

2-Pyrrolidinone

N-Benzyl-4-piperidone Structure

N-Benzyl-4-pipe...

~%

1-(1-Benzylpiperidin-4-yl)pyrrolidin-2-one Structure

1-(1-Benzylpipe...

4-Piperidinemethanol Structure

4-Piperidinemethanol

~%

1-Boc-4-Morpholin-4-ylmethyl-piperidine Structure

1-Boc-4-Morphol...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

1-Boc-4-Morpholin-4-ylmethyl-piperidine Structure

1-Boc-4-Morphol...

1-Boc-4-piperidinemethanol Structure

1-Boc-4-piperid...

~%

1-Boc-4-Morpholin-4-ylmethyl-piperidine Structure

1-Boc-4-Morphol...

4-Piperidinemethanol Structure

4-Piperidinemethanol

~%

1-Boc-4-(2-thioxopiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(2-thio...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

1-Boc-4-(2-thioxopiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(2-thio...

1-Boc-4-piperidinemethanol Structure

1-Boc-4-piperid...

~%

1-Boc-4-(2-thioxopiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(2-thio...

Piperidine-2-thione Structure

Piperidine-2-thione

1-Boc-piperidine-4-carboxaldehyde Structure

1-Boc-piperidin...

~%

1-Boc-4-(2-thioxopiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(2-thio...

4-Piperidinemethanol Structure

4-Piperidinemethanol

~%

1-(piperidin-4-ylmethyl)piperidine Structure

1-(piperidin-4-...

1-Boc-4-piperidinemethanol Structure

1-Boc-4-piperid...

~%

1-(piperidin-4-ylmethyl)piperidine Structure

1-(piperidin-4-...

1-Boc-piperidine-4-carboxaldehyde Structure

1-Boc-piperidin...

~%

1-(piperidin-4-ylmethyl)piperidine Structure

1-(piperidin-4-...

1-(1-benzylpiperidin-4-yl)pyrrolidin-3-ol Structure

1-(1-benzylpipe...

~%

1-(4-PIPERIDINYL)-3-PYRROLIDINOL Structure

1-(4-PIPERIDINY...

N-Benzyl-4-piperidone Structure

N-Benzyl-4-pipe...

~%

1-(4-PIPERIDINYL)-3-PYRROLIDINOL Structure

1-(4-PIPERIDINY...

4-Piperidinemethanol Structure

4-Piperidinemethanol

~%

1-Boc-4-[2-(2-hydroxyethyl)piperidin-1-ylmethyl]piperidine Structure

1-Boc-4-[2-(2-h...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

1-Boc-4-[2-(2-hydroxyethyl)piperidin-1-ylmethyl]piperidine Structure

1-Boc-4-[2-(2-h...

1-Boc-4-piperidinemethanol Structure

1-Boc-4-piperid...

~%

1-Boc-4-[2-(2-hydroxyethyl)piperidin-1-ylmethyl]piperidine Structure

1-Boc-4-[2-(2-h...

β-Piperidylethanol Structure

β-Piperidylethanol

1-Boc-piperidine-4-carboxaldehyde Structure

1-Boc-piperidin...

~%

1-Boc-4-[2-(2-hydroxyethyl)piperidin-1-ylmethyl]piperidine Structure

1-Boc-4-[2-(2-h...

4-Piperidinemethanol Structure

4-Piperidinemethanol

~%

1-Boc-4-(3-isopropylcarbamoyloxypiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-isop...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

1-Boc-4-(3-isopropylcarbamoyloxypiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-isop...

1-Boc-4-piperidinemethanol Structure

1-Boc-4-piperid...

~%

1-Boc-4-(3-isopropylcarbamoyloxypiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-isop...

4-Piperidinemethanol Structure

4-Piperidinemethanol

~%

1-Boc-4-(3-benzyl-2-oxopiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-benz...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

1-Boc-4-(3-benzyl-2-oxopiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-benz...

1-Boc-4-piperidinemethanol Structure

1-Boc-4-piperid...

~%

1-Boc-4-(3-benzyl-2-oxopiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-benz...

3-phenylmethyl-2-piperidinone Structure

3-phenylmethyl-...

1-Boc-piperidine-4-carboxaldehyde Structure

1-Boc-piperidin...

~%

1-Boc-4-(3-benzyl-2-oxopiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-benz...

4-Piperidinemethanol Structure

4-Piperidinemethanol

~%

1-Boc-4-(3-hydroxypiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-hydr...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

1-Boc-4-(3-hydroxypiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-hydr...

1-Boc-4-piperidinemethanol Structure

1-Boc-4-piperid...

~%

1-Boc-4-(3-hydroxypiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-hydr...

3-Hydroxypiperidine Structure

3-Hydroxypiperidine

1-Boc-piperidine-4-carboxaldehyde Structure

1-Boc-piperidin...

~%

1-Boc-4-(3-hydroxypiperidin-1-ylmethyl)piperidine Structure

1-Boc-4-(3-hydr...

Synthesis of substituted 4 (Z)-(methoxyimino) pentyl-1-piper...

[Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 491 - 494]

Synthesis of substituted 4 (Z)-(methoxyimino) pentyl-1-piper...

[Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 491 - 494]

Synthesis of substituted 4 (Z)-(methoxyimino) pentyl-1-piper...

[Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 491 - 494]