Journal of Combinatorial Chemistry 2010-07-12

One-step synthesis of diarylpyrazolo[3,4-b]pyridines from isoflavones.

Zun-Ting Zhang, Yong Liang, Yu-Qing Ma, Dong Xue, Jun-Ling Yang

文献索引：J. Comb. Chem. 12(4) , 600-3, (2010)

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摘要

A new concise, facile, and efficient method for the synthesis of 3-hydroxy-5,6-diphenylpyrazolo[3,4-b]pyridine derivatives has been described. The cyclocondensation of isoflavones with 3-amino-5-hydroxypyrazole in the presence of sodium methoxide gave fused heteroaromatic 3-hydroxy-5,6-diphenylpyrazolo[3,4-b]pyridines in moderate to good yields.