Organic Letters 2006-03-30

Catalytic asymmetric addition of dimethylzinc to alpha-ketoesters, using mandelamides as ligands.

Gonzalo Blay, Isabel Fernandez, Alícia Marco-Aleixandre, José R Pedro

文献索引：Org. Lett. 8(7) , 1287-90, (2006)

全文：HTML全文

摘要

[reaction: see text] A strategy based on the control of the electron-donating capabilities of the coordinating groups of the ligand has been applied in the catalytic asymmetric addition of organometallic reagents to ketoesters. Mandelamides having deprotonated alcohol and carboxyamido groups catalyzed the addition of dimethylzinc to alpha-ketoesters with good yields and ee (up to 90%).