A Ring??Closing Metathesis Pathway to Fluorovinyl??Containing Nitrogen Heterocyles

V De Matteis, FL van Delft, J Tiebes…

文献索引：De Matteis, Valeria; Van Delft, Floris L.; Tiebes, Joerg; Rutjes, Floris P. J. T. European Journal of Organic Chemistry, 2006 , # 5 p. 1166 - 1176

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被引用次数: 17

摘要

Abstract The synthesis of highly functionalized fluorinated piperidines is described. The key step in this synthesis is a ring-closing metathesis reaction involving fluoride-substituted olefins, which leads to the corresponding cyclic vinyl fluorides. Several sequences to arrive at differently substituted piperidines have been evaluated.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)