Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform

TP Heffron, BQ Wei, A Olivero, ST Staben…

文献索引：Journal of Medicinal Chemistry, , vol. 54, # 22 p. 7815 - 7833

被引用次数: 25

摘要

... Journal of Medicinal Chemistry. ... for its potential in cancer therapy. Herein we report our successful approaches to achieve PI3Kα vs PI3Kβ selectivity for two chemical series. In the thienopyrimidine series of inhibitors ...

4651-81-4

2-氨基噻吩-3-羧酸甲酯

18740-38-0

2,4-二羟基噻吩[2,3-D]嘧啶

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