Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform

TP Heffron, BQ Wei, A Olivero, ST Staben…

Index: Journal of Medicinal Chemistry, , vol. 54, # 22 p. 7815 - 7833

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Citation Number: 25

Abstract

... Journal of Medicinal Chemistry. ... for its potential in cancer therapy. Herein we report our successful approaches to achieve PI3Kα vs PI3Kβ selectivity for two chemical series. In the thienopyrimidine series of inhibitors ...

The highly potent and selective dipeptidyl peptidase IV inhi...

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Selective Kainate Receptor (GluK1) Ligands Structurally Base...

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A Convenient Synthesis of New 3, 7-Diphenylthieno [3, 2-e] b...

[Son, Hoon Young; Song, Yang-Heon Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 8 p. 2242 - 2246]