Synthesis and Nucleic Acids Binding Properties of Diastereomeric Aminoethylprolyl Peptide Nucleic Acids (aep PNA)

P Ngamwiriyawong, T Vilaivan

文献索引：Ngamwiriyawong, Patcharee; Vilaivan, Tirayut Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 2 p. 97 - 112

全文：HTML全文

被引用次数: 3

摘要

A general synthetic method for Fmoc-protected monomers of all four diastereomeric aminoethyl peptide nucleic acid (aep PNA) has been developed. The key reaction is the coupling of nucleobase-modified proline derivatives and Fmoc-protected aminoacetaldehyde by reductive alkylation. Oligomerization of the aep PNAs up to 10mer was achieved by Fmoc-solid phase peptide synthesis methodology. Preliminary binding ...