Synthesis and Nucleic Acids Binding Properties of Diastereomeric Aminoethylprolyl Peptide Nucleic Acids (aep PNA)

P Ngamwiriyawong, T Vilaivan

Index: Ngamwiriyawong, Patcharee; Vilaivan, Tirayut Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 2 p. 97 - 112

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Citation Number: 3

Abstract

A general synthetic method for Fmoc-protected monomers of all four diastereomeric aminoethyl peptide nucleic acid (aep PNA) has been developed. The key reaction is the coupling of nucleobase-modified proline derivatives and Fmoc-protected aminoacetaldehyde by reductive alkylation. Oligomerization of the aep PNAs up to 10mer was achieved by Fmoc-solid phase peptide synthesis methodology. Preliminary binding ...