Achieving multi-isoform PI3K inhibition in a series of substituted 3, 4-dihydro-2H-benzo [1, 4] oxazines

B Perry, R Alexander, G Bennett, G Buckley…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 16 p. 4700 - 4704

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被引用次数: 21

摘要

... Bioorganic & Medicinal Chemistry Letters. ... a UCB, Medicinal Chemistry, Granta Park, Great Abington ... 8 Compound 1 was considered a promising chemical starting point due to its low molecular weight and resultant high ligand efficiency (0.4164 kcal mol −1 against PI3Kγ). ...