Journal of Biological Chemistry

Novel coenzyme B12-dependent interconversion of isovaleryl-CoA and pivalyl-CoA

V Cracan, R Banerjee

文献索引：Cracan, Valentin; Banerjee, Ruma Journal of Biological Chemistry, 2012 , vol. 287, # 6 p. 3723 - 3732

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被引用次数: 14

摘要

Background: IcmF is a fusion between a coenzyme B 12-dependent isobutyryl-CoA/n-butyryl- CoA isomerase and a G-protein chaperone. Results: IcmF also isomerizes isovaleryl-CoA to pivalyl-CoA and is partially protected from inactivation in the presence of GTP. Conclusion: The isovaleryl-CoA mutase activity of IcmF might be important in leucine catabolism where isovaleric acid is an intermediate.