Tetrahedron

Palladium-catalyzed direct arylation of thiazoles with aryl bromides

A Yokooji, T Okazawa, T Satoh, M Miura, M Nomura

文献索引：Yokooji, Aya; Okazawa, Toru; Satoh, Tetsuya; Miura, Masahiro; Nomura, Masakatsu Tetrahedron, 2003 , vol. 59, # 30 p. 5685 - 5689

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被引用次数: 136

摘要

Thiazole, 2-phenyl or-alkyl substituted one and benzothiazole are efficiently arylated with aryl bromides at the 2-and/or 5-position (s) in the presence of Pd (OAc) 2 and a bulky phosphine ligand using Cs2CO3 as base. 2-Phenyl-5-thiazolecarboxanilide undergoes successive diarylation at the 4-and 5-positions accompanied by decarbamoylation.