Human Psychopharmacology: Clinical and Experimental 2005-10-01

Double-blind study of cyamemazine and diazepam in the alcohol withdrawal syndrome.

Jean-Daniel Favre, Hervé Allain, Henri-Jean Aubin, Elisabeth Frija-Orvoen, Claudine Gillet, Michel Lejoyeux, Alain Payen, Michel Weber, Stéphanie Garcia-Acosta, Imane Kermadi, Michel Dib

文献索引：Hum. Psychopharmacol. Clin. Exp. 20(7) , 511-9, (2005)

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摘要

Cyamemazine is an original phenothiazine derivative which showed similar efficacy and tolerability to lorazepam during ethanol withdrawal in mice. This study investigated cyamemazine for its efficacy and tolerability in alcohol-dependent patients electing an alcohol withdrawal procedure, in comparison with diazepam.A multicenter, randomized, double-blind study in 89 alcohol-dependent patients (CIWA-Ar score between 10 and 30), electing an alcohol withdrawal procedure, was used to find effective doses of cyamemazine and to compare it with diazepam for efficacy and tolerability. On day 1 (D(1)), cyamemazine or diazepam (50 mg and 10 mg capsule, respectively) were administered at hourly intervals to reduce CIWA-Ar = 5, up to a maximum of eight administrations. Starting from D(2), the compounds were given twice a day in progressively decreasing doses during a maximum period of 13 days (D(end)).At h(8) (8 h after the first treatment of D(1)), therapeutic success (CIWA-Ar score