Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance

…, V Fernandez-Vega, P Hodder, H Rosen…

文献索引：Tsuboi, Katsunori; Bachovchin, Daniel A.; Speers, Anna E.; Spicer, Timothy P.; Fernandez-Vega, Virneliz; Hodder, Peter; Rosen, Hugh; Cravatt, Benjamin F. Journal of the American Chemical Society, 2011 , vol. 133, # 41 p. 16605 - 16616

全文：HTML全文

被引用次数: 36

摘要

Glutathione S-transferases (GSTs) are a superfamily of enzymes that conjugate glutathione to a wide variety of both exogenous and endogenous compounds for biotransformation and/or removal. Glutathione S-tranferase omega 1 (GSTO1) is highly expressed in human cancer cells, where it has been suggested to play a role in detoxification of chemotherapeutic agents. Selective inhibitors of GSTO1 are, however, required to test the ...