Organic letters

Microbial deracemization of α-substituted carboxylic acids

D Kato, S Mitsuda, H Ohta

文献索引：Kato, Dai-ichiro; Mitsuda, Satoshi; Ohta, Hiromichi Organic letters, 2002 , vol. 4, # 3 p. 371 - 373

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被引用次数: 36

摘要

In this Letter, we report a preparation of optically active α-substituted carboxylic acids via a novel enzymatic deracemization reaction using whole cells. This deracemization reaction inverts the chirality of one enantiomer of a racemate to the other antipode, resulting in an optically active compound starting from a racemic mixture. Thus this process is entirely different from the above-mentioned dynamic resolution, 2 because in this reaction the starting material and ...