Chemical Biology & Drug Design 2009-06-01

Novel pleuromutilin derivatives with excellent antibacterial activity against Staphylococcus aureus.

Peng Xu, Yuan-Yuan Zhang, Yong-Xue Sun, Jian-Hua Liu, Bing Yang, Yu-Zhong Wang, Yu-Liang Wang

文献索引：Chem. Biol. Drug Des. 73(6) , 655-60, (2009)

摘要

Ten novel pleuromutilin derivatives with thioether moiety and heterocyclic carboxamide or chloroformate group in the side chain were synthesized and confirmed by (1)H NMR, IR and HRMS. The results of the antibacterial activity showed that the title compounds had excellent antibacterial activity against Staphylococcus aureus, among which the MIC of 5f reached 0.03125 microg/mL.

结构式	名称/CAS号	分子式	全部文献
	截短侧耳素 CAS:125-65-5	C₂₂H₃₄O₅

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Novel pleuromutilin derivatives with excellent antibacterial activity against Staphylococcus aureus.

摘要

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