Bioorganic & Medicinal Chemistry Letters 1998-07-07

Inhibitors of the bacterial cell wall biosynthesis enzyme MurD.

L D Gegnas, S T Waddell, R M Chabin, S Reddy, K K Wong

文献索引：Bioorg. Med. Chem. Lett. 8 , 1643-8, (1998)

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摘要

A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.