Bioorganic & Medicinal Chemistry Letters 1998-07-07

Inhibitors of the bacterial cell wall biosynthesis enzyme MurD.

L D Gegnas, S T Waddell, R M Chabin, S Reddy, K K Wong

Index: Bioorg. Med. Chem. Lett. 8 , 1643-8, (1998)

Full Text: HTML

Abstract

A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.