Defined dimensional alterations in enzyme substrates. General synthetic methodology for the bent dihydro-lin-benzopurines

TM Stevenson, F Kazmierczak…

文献索引：Stevenson, Thomas M.; Kazmierczak, Franciszek; Leonard, Nelson J. Journal of Organic Chemistry, 1986 , vol. 51, # 5 p. 616 - 620

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被引用次数: 20

摘要

Naturally occurring, modified, and substituted purines have been subjected to close scrutiny by scientists seeking to establish structure-biological activity relationships. The need for more information defining the active sites of enzymes that require purines as substrates or cofactors has led to the synthesis of an ordered series of compounds which we refer to as dimensional pr0bes. l These compounds retain both the pyrimidine and imidazole rings ...