Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors

GS Sant'Anna, P Machado, PD Sauzem…

文献索引：Sant' Anna, Gabriela da S.; Machado, Pablo; Sauzem, Patricia D.; Rosa, Fernanda A.; Rubin, Maribel A.; Ferreira, Juliano; Bonacorso, Helio G.; Zanatta, Nilo; Martins, Marcos A.P. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 546 - 549

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被引用次数: 35

摘要

A series of sixteen 2-substituted-2-imidazolines (where the substituent R= Ph, Me-4-Ph; MeO-4-Ph;(MeO) 2-3, 4-Ph;(MeO) 3-3, 4, 5-Ph; Ph-4-OC (O)-Ph; Cl-4-Ph; Cl-2-Ph; Cl2-2, 4- Ph; NO2-4-Ph; NO2-3-Ph; Naphth-2-yl; Fur-2-yl; Benzofur-2-yl; Pyridin-2-yl; Quinolin-2-yl) has been synthesized from the reaction of the substituted-aldehydes and ethylenediamine by ultrasound irradiation with NBS in an aqueous medium in high yields (80–99%). The 2- ...