European Journal of Medicinal Chemistry 2009-11-01

Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones.

Tanvir Hussain, Hamid Latif Siddiqui, Muhammad Zia-ur-Rehman, Muhammad Masoom Yasinzai, Masood Parvez

文献索引：Eur. J. Med. Chem. 44 , 4654-60, (2009)

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摘要

A series of new 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones were synthesized by the condensation of various acetophenones with 4-(1H-imidazol-1-yl) benzaldehyde which was itself prepared by the N-arylation of imidazole using hexadecyltrimethylammonium bromide as catalyst for the first time. All the synthesized compounds were subjected to preliminary evaluation for their anti-leishmanial, anti-oxidant and anti-fungal activities. Few of the synthesized compounds showed significant activities.