Organic letters

DMF as Carbon Source: Rh-Catalyzed α-Methylation of Ketones

Y Li, D Xue, W Lu, C Wang, ZT Liu, J Xiao

文献索引：Li, Yang; Xue, Dong; Lu, Wei; Wang, Chao; Liu, Zhao-Tie; Xiao, Jianliang Organic Letters, 2014 , vol. 16, # 1 p. 66 - 69

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被引用次数: 29

摘要

An unprecedented Rh-catalyzed direct methylation of ketones with N, N-dimethylformamide (DMF) is disclosed. The reaction shows a broad substrate scope, tolerating both aryl and alkyl ketones with various substituents. Mechanistic studies suggest that DMF delivers a methylene fragment followed by a hydride in the methylation process.

68-12-2

N,N-二甲基甲酰胺

121-97-1

4'-甲氧基苯丙酮

~71%

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~25%

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~64%

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~62%

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~64%

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~72%

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~69%

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~59%

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~43%

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~62%

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~73%

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~45%

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~65%

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~68%

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~74%

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~56%

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~56%

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~70%

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~44%

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~63%

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~60%

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~62%

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~63%

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