In vitro and in vivo anti-tumoral activities of imidazo [1, 2-a] quinoxaline, imidazo [1, 5-a] quinoxaline, and pyrazolo [1, 5-a] quinoxaline derivatives

G Moarbess, C Deleuze-Masquefa, V Bonnard…

文献索引：Moarbess, Georges; Deleuze-Masquefa, Carine; Bonnard, Vanessa; Gayraud-Paniagua, Stephanie; Vidal, Jean-Remi; Bressolle, Francoise; Pinguet, Frederic; Bonnet, Pierre-Antoine Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 13 p. 6601 - 6610

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被引用次数: 47

摘要

Imidazoquinoxaline and pyrazoloquinoxaline derivatives, analogues of imiquimod, were synthesized, and their in vitro cytotoxic and pharmacodynamic activities were evaluated. In vitro cytotoxicity studies were assessed against melanoma (A375, M4Be, RPMI-7591), colon (LS174T), breast (MCF7), and lymphoma (Raji) human cancer cell lines. In vivo studies were carried out in M4Be xenografted athymic mice. EAPB0103, EAPB0201, EAPB0202, and ...