In vitro and in vivo anti-tumoral activities of imidazo [1, 2-a] quinoxaline, imidazo [1, 5-a] quinoxaline, and pyrazolo [1, 5-a] quinoxaline derivatives

G Moarbess, C Deleuze-Masquefa, V Bonnard…

Index: Moarbess, Georges; Deleuze-Masquefa, Carine; Bonnard, Vanessa; Gayraud-Paniagua, Stephanie; Vidal, Jean-Remi; Bressolle, Francoise; Pinguet, Frederic; Bonnet, Pierre-Antoine Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 13 p. 6601 - 6610

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Citation Number: 47

Abstract

Imidazoquinoxaline and pyrazoloquinoxaline derivatives, analogues of imiquimod, were synthesized, and their in vitro cytotoxic and pharmacodynamic activities were evaluated. In vitro cytotoxicity studies were assessed against melanoma (A375, M4Be, RPMI-7591), colon (LS174T), breast (MCF7), and lymphoma (Raji) human cancer cell lines. In vivo studies were carried out in M4Be xenografted athymic mice. EAPB0103, EAPB0201, EAPB0202, and ...