Tetrahedron: Asymmetry

A convenient chemoenzymatic synthesis of (R)-(−) and (S)-(+)-homo-β-proline

F Felluga, V Gombac, G Pitacco, E Valentin

文献索引：Felluga, Fulvia; Gombac, Valentina; Pitacco, Giuliana; Valentin, Ennio Tetrahedron Asymmetry, 2004 , vol. 15, # 20 p. 3323 - 3327

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被引用次数: 19

摘要

Both enantiomers of the heterocyclic GABA analogue homo-β-proline (3-pyrrolidineacetic acid) were synthesized by a chemoenzymatic method involving the use of two enantiocomplementary enzymes in the disymmetric hydrolyses of 3-nitromethylglutaric acid diethyl ester.