Synthesis

A practical ex-chiral-pool synthesis of β-proline and homo-β-proline

C Thomas, F Orecher, P Gmeiner

文献索引：Thomas, Christoph; Orecher, Florian; Gmeiner, Peter Synthesis, 1998 , # 10 p. 1491 - 1496

全文：HTML全文

被引用次数: 18

摘要

Abstract: Starting from aspartic acid an efficient synthesis of enantiomerically pure β-proline and homo-β-proline is described. The key step of the synthesis includes formation of the 1, 4- biselectrophile 6, followed by rearrangement via the aziridinium intermediate 7 and ring closure to give the pyrrolidinium salt 9a which can serve as a common precursor for both target compounds. Key words: β-proline, homo-β-proline, aziridinium intermediate, ...