European journal of medicinal chemistry

Synthesis and QSAR studies of novel 1-substituted-2-aminobenzimidazoles derivatives

X Guida, H Jianhua, L Xiaomin

文献索引：Guida, Xuan; Jianhua, Han; Xiaomin, Li European Journal of Medicinal Chemistry, 2006 , vol. 41, # 9 p. 1080 - 1083

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被引用次数: 11

摘要

A series of novel 1-substituted-2-aminobenzimidazole derivatives were synthesized. The structures of the synthesized compounds were confirmed by 1H-NMR spectra and by elemental analysis. Acute toxicities of these compounds were detected on mice via toxicity (logLD50). QSAR analysis of these chemicals was studied on the relationship between acute toxicity and the octanol/water partition coefficient (LogP). The products were ...