Toxicology letters

Characterization of 2-amino-1-benzylbenzimidazole and its metabolites using tandem mass spectrometry

O Ogunbiyi, M Kajbaf, JH Lamb, M Jahanshahi…

文献索引：Ogunbiyi, O.; Kajbaf, M.; Lamb, J. H.; Jahanshahi, M.; Gorrod, J. W.; Naylor, S. Toxicology Letters, 1995 , vol. 78, # 1 p. 25 - 34

全文：HTML全文

被引用次数: 4

摘要

We have investigated the in vitro hamster hepatic microsomal metabolism of the amino- azaheterocycle, 2-amino-1-benzylbenzimidazole (ABB). Three major metabolites were isolated and structurally characterized, using a combination of off-line HPLC, in conjunction with both electron ionization and fast atom bombardment ionization tandem mass spectrometry. ABB was shown to be debenzylated to afford 2-aminobenzimidazole (AB), ...