Synthesis and initial SAR studies of 3, 6-disubstituted pyrazolo [1, 5-a] pyrimidines: a new class of KDR kinase inhibitors

ME Fraley, WF Hoffman, RS Rubino…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 19 p. 2767 - 2770

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被引用次数: 114

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Departments of Medicinal Chemistry and Cancer Research, Merck Research Laboratories, West Point, PA 19486, USA. ... Our chemistry efforts began with the goal of improving the activity of screening lead 1 (Fig. 1, KDR IC 50 =224 nM). ...