Microwave-assisted protocols for the expedited synthesis of pyrazolo [1, 5-a] and [3, 4-d] pyrimidines

…, EP Lebois, H Muchalski, M Hughes, CW Lindsley

文献索引：Daniels, R. Nathan; Kim, Kwangho; Lebois, Evan P.; Muchalski, Hubert; Hughes, Mary; Lindsley, Craig W. Tetrahedron Letters, 2008 , vol. 49, # 2 p. 305 - 310

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被引用次数: 55

摘要

General, high-yielding MAOS protocols for the expedited synthesis of functionalized pyrazolo [1, 5-a] pyrimidines and pyrazolo [3, 4-b] pyrimidines, as well as their pyrazole precursors, are described amenable to an iterative analogue library synthesis strategy for lead optimization.