Journal of Combinatorial Chemistry 2008-01-01

Novel and efficient one-pot tandem synthesis of 2-styryl-substituted 4(3H)-quinazolinones.

Minoo Dabiri, Mostafa Baghbanzadeh, Akram Sadat Delbari

文献索引：J. Comb. Chem. 10(5) , 700-3, (2008)

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摘要

A novel one-pot tandem synthesis of 2-styryl-4(3 H)-quinazolinones in an acidic ionic liquid is reported. In this procedure isatoic anhydride, a primary aniline or ammonium acetate, and triethylorthoacetate are reacted in the presence of imidazolium trifluoroacetate [Hmim]TFA. Subsequently an aromatic aldehyde is added to the mixture to afford the title compounds in high to excellent yields.