Bacterial siderophores: synthesis and biological activities of novel pyochelin analogues

A Zamri, IJ Schalk, F Pattus, MA Abdallah

文献索引：Zamri; Schalk; Pattus; Abdallah Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1147 - 1150

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被引用次数: 17

摘要

The synthesis and biological activities of four pyochelin analogues substituted in different parts of the molecule are reported: 5-NHBoc-pyochelin, 3 ″N-Boc-pyochelin, 3 ″-nor-NH- pyochelin and neopyochelin II, the enantiomer of natural pyochelin. All these compounds complex iron (III) and transport it at different rates into the cells of Pseudomonas aeruginosa.