The synthesis and biological activities of four pyochelin analogues substituted in different parts of the molecule are reported: 5-NHBoc-pyochelin, 3 ″N-Boc-pyochelin, 3 ″-nor-NH- pyochelin and neopyochelin II, the enantiomer of natural pyochelin. All these compounds complex iron (III) and transport it at different rates into the cells of Pseudomonas aeruginosa.
