P2O5SiO2: A Simple and Effective Catalyst for the Synthesis of Nsubstituted 1-Alkyl and 1-Aryl 3-Aminoisoquinolines

LJ Mendez, AS Canepa, R Rimada…

文献索引：Mendez, Leticia J.; Canepa, Alicia S.; Rimada, Ruben; Bravo, Rodolfo D. Letters in Organic Chemistry, 2013 , vol. 10, # 4 p. 240 - 244

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摘要

A synthesis of N-substituted 1-alkyl and 1-aryl 3-aminoisoquinolines by cyclocondensation of 2-acylphenylacetonitriles with aliphatic and aromatic amines using P2O5/SiO2 as catalysts is described. Selectivity, simplicity of operation and easy work-up are some advantages of this method.