European Journal of Medicinal Chemistry 2004-07-01

QSAR study on carbonic anhydrase inhibitors: aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties, with topical activity as antiglaucoma agents.

Vijay K Agrawal, Shahnaz Bano, Claudiu T Supuran, Padmakar V Khadikar

文献索引：Eur. J. Med. Chem. 39(7) , 593-600, (2004)

摘要

Quantitative structure-activity-relationship (QSAR) study on aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl carbonic anhydrase (CA) inhibitors has been carried out topologically using first-order valence connectivity index ((1)chi(v)). Excellent results are obtained against all the three isozymes; CA I, II and IV of the zinc enzyme CA by using indicator parameters along with (1)chi(v).

结构式	名称/CAS号	分子式	全部文献
	8-喹啉磺酰氯 CAS:18704-37-5	C₉H₆ClNO₂S

Carbonic anhydrase inhibitors: synthesis of water-soluble, t...
1999-11-01
[Bioorg. Med. Chem. 7(11) , 2397-406, (1999)]

H. Takaku et al.
[J. Org. Chem. 45 , 3347, (1980)]

H. Takaku, M. Yoshida
[J. Org. Chem. 46 , 589, (1981)]

H. Takaku et al.
[J. Org. Chem. 48 , 1399, (1983)]

E.J. Corey et al.
[J. Org. Chem. 54 , 389, (1989)]

QSAR study on carbonic anhydrase inhibitors: aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties, with topical activity as antiglaucoma agents.

摘要

相关化合物