Chemical Communications

Friedel–Crafts-type reactions with ureas and thioureas

EK Raja, SON Lill, DA Klumpp

文献索引：Raja, Erum K.; Nilsson Lill, Sten O.; Klumpp, Douglas A. Chemical Communications, 2012 , vol. 48, # 65 p. 8141 - 8143

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被引用次数: 8

摘要

Despite the relatively low reactivities of urea and thiourea functional groups towards nucleophilic attack, we have found conditions in which they are useful substrates in Friedel– Crafts reactions. The Brønsted superacid, triflic acid, promotes these reactions and a mechanism is proposed involving dicationic, superelectrophilic intermediates.