Behavioural Brain Research 2012-07-15

Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice

Gyula Telegdy, Andrew V. Schally, Gyula Telegdy, Andrew V. Schally, Gyula Telegdy, Andrew V. Schally

文献索引：Behav. Brain Res. 233(1) , 232-6, (2012)

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摘要

Highlights ► The involvement of transmitters in the anxiolytic action of GH-RH antagonist, MZ-4-71, has been tested in plus maze. ► In the experiments the animals were pretreated with phenoxybenzamine, prazosin, yohimbine, methysergide,cyproheptadine and bicuculline. ► The anxiolytic action of MZ-471 was elicited via α1/α2-adrenergic, 5HT1/5HT2 serotonergic and GABA-A-ergic mechanism.