Trifluoromethylation of non-activated aldimines with trimethyl (trifluoromethyl) silane in the presence of tetramethylammonium fluoride: A closer look into the reaction …

…, W Tyrra, D Naumann, HTM Fischer, H Scherer

文献索引：Kirij, Nataliya V.; Babadzhanova, Lesya A.; Movchun, Valeria N.; Yagupolskii, Yurii L.; Tyrra, Wieland; Naumann, Dieter; Fischer, Hendrik T.M.; Scherer, Harald Journal of Fluorine Chemistry, 2008 , vol. 129, # 1 p. 14 - 21

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被引用次数: 24

摘要

The reactions of non-activated aldimines with trimethyl (trifluoromethyl) silane and 1equiv. of tetramethylammonium fluoride proceed via the formation of tetramethylammonium amides which were identified by low-temperature 19F NMR experiments. Consecutive reactions of the salts formed in situ with electrophiles yielded trifluoromethylated amines. Fluoride elimination is observed in the absence of electrophilic substrates leading to the formation ...