Nucleosides, Nucleotides & Nucleic Acids 2007-01-01

Transformation of D-(-)-ribose into a natural product-like scaffold via a Lewis acid catalyzed intramolecular hetero-Diels-Alder reaction.

Roland Messer, Cyril A Fuhrer, Robert Häner

文献索引：Nucleosides Nucleotides Nucleic Acids 26(6-7) , 701-4, (2007)

全文：HTML全文

摘要

Starting from D-(-)-ribose, a tricyclic natural product-like scaffold suitable for combinatorial derivatization was synthesized via an intramolecular hetero-Diels-Alder reaction. Lithium perchlorate was found to enhance the reaction rate and, at the same time, had a pronounced influence on the chemoselectivity of the reaction. The stereochemical course of the reaction, however, was not influenced by the Lewis acid.