Building a sulfonamide library by eco-friendly flow synthesis

…, M Teofrasti, P Filipponi, R Pellicciari

文献索引：Gioiello, Antimo; Rosatelli, Emiliano; Teofrasti, Michela; Filipponi, Paolo; Pellicciari, Roberto ACS Combinatorial Science, 2013 , vol. 15, # 5 p. 235 - 239

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被引用次数: 15

摘要

A rapid and eco-friendly synthesis of a sulfonamide library under flow conditions is described. The study illustrates an efficient, safe, and easily scalable preparation of sulfonamides by use of a meso-reactor apparatus, thus demonstrating the impact of flow technologies within drug discovery. Waste minimization, employment of green media, and nontoxic reactants are achieved by the optimization of the flow setup and experimental ...